Learn to walk like a penguin to prevent winter falls. Hazardous identification material safety data sheet material metformin hydrochloride extendedrelease tablets 500 mg and mg manufacturer lupin limited goa 403 722 india. Etoricoxib caused significantly fewer ulcers and erosions than naproxen. Material safety data sheet page 1 of 8 pfizer inc pfizer pharmaceuticals group 235 east 42nd street new york, new york 10017 12125732222. Etoricoxib may slightly increase your risk of heart attack and stroke and. Therefore, hypertension should be controlled before treatment with etoricoxib see section 4. Some lumber products may be sprayed with sap stain control coatings. Dannunzio, co palazzina delle scuole di specializzazione, via dei vestini 31, 660 chieti, italy. Inhibition of cox2 may induce apoptosis and inhibit tumor cell proliferation and. Safety data sheets sdss formerly known as material safety data sheets or. Etoricoxib crosses the placenta in rats and rabbits, and the bloodbrain barrier in rats. Etoricoxib may be given to a broad range of patients without need for dosage adjustment, except in cases of hepatic insufficiency. First aid measures first aid measures general advice immediate medical attention is required.
This document has been prepared in accordance with standards for. Describes the effects when workers come into contact with the chemical and how to proceed in case of an accident. Not a dangerous good if item is equal to or less than 1gml and there is less than 100gml in the package. Product and company identification space synonyms softwood plywood oriented strand board osb hardboard standard, tempered, perforated, paneling lumber products engineered lumber lvl, woodijoists. Both referral procedures pertained to the safety of the cox2 inhibitor products, including etoricoxib, with a particular focus on gastrointestinal gi. Dissolution rate studies on etoricoxib formulations. For research use only, not for human or veterinary use. Etoricoxib vetranal, analytical standard sigmaaldrich. Dissolution rate of etoricoxib as such from formulations was studied using lab india disso 2000, an 8 stage dissolution rate testing apparatus, with a paddle stirrer. Stability studies in combine dosage form of etoricoxib and.
Hazardous identification material safety data sheet material telmisartan and hydrochlorothiazide tablets usp 40 mg12. It provides an alternative to other selective and traditional nsaids in treating patients with arthritis and other painful conditions. If you think any of these are relevant to you, do not take the tablets until you. The recommended dose is 60 mg etoricoxib once a day. Study the material safety data sheets for the hazards of the chemical, learn the instructions on handling, storage and the emergency measures in case of accident take our free online course to learn how to to properly apply and use your msds complete a full risk assessment for your workplace so that you can map out all the hazards into a single comprehensive coshh assessment. Validated reverse phase hplc method for the determination of impurities in etoricoxib article pdf available in ejournal of chemistry 8s1 december 2011 with 548 reads how we measure reads. Desmethyl etoricoxib is an impurity of etoricoxib e934100 which is a specific inhibitor of cox2. Material may be irritating to the mucous membranes and upper respiratory tract. Etoricoxib is a cox2 inhibitor with a high degree of selectivity for its target. Both referral procedures pertained to the safety of the cox2 inhibitor products, including etoricoxib, with a particular focus on gastrointestinal gi and cardiovascular cv safety.
Eye contact rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. The real benefit to harm balance of this derivative is still unknown. Show this safety data sheet to the doctor in attendance. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase2 cox2, resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Etoricoxib 5chloro26methylpyridin3yl3 4methyl sulfonylphenylpyridine is an orally active, selective cyclooxygenase2 inhibitor 5.
Etoricoxib was included in previous chmp referrals on the safety of cox2 selective inhibitors in which concluded in 2004 and 2005. Additionally, phone and email consultation services are available to provide counseling on test submission, result. It is a poorly soluble and highly permeable bcs class 2 drug 6. The dose can be increased to a maximum of 90 mg once a day if needed. Etoricoxib safety data sheet according to regulation ec no. Safety of etoricoxib in patients with reactions to nsaids. Pdf identification of etoricoxib polymorphic crystalline. Qualitative and quantitative composition each filmcoated tablet contains 30, 60, 90 or 120 mg of etoricoxib. Etoricoxib is a synthetic, nonsteroidal antiinflammatory drug nsaid with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib united states pharmacopeia usp reference. Etoricoxib is a member of the class of bipyridines that is 2,3bipyridine which is substituted at the 3, 5, and 6 positions by 4 methylsulfonylphenyl, chlorine, and methyl groups, respectively.
By reducing the synthesis of inflammatory mediators, etoricoxib can modify the pain response. Etoricoxib is highly selective for cox2 ic 50 ratio, 344. Material safety data sheet fluconazole msds section 1. Msds includes information such as melting point, boiling point, and flash point of a hazardous material. Extend your arms to keep your balance, point your feet slightly outward. Etoricoxib manufacturer in india exporter in india etoricoxib 60 mg, etoricoxib 90 mg,etoricoxib 120 mg largest generic manufacturer,drugs,formula,producing etoricoxib msds,coa, pdf,doc chemical api method according to the present etoricoxib invention suppliers list,molecular structure,weight,iupac,synonyms for etoricoxib. Stock solution of etoricoxib btransferred an accurately quantity 60. These sdss are designed to provide essential information. Identification of the substancemixture and of the companyundertaking product name. Sep 17, 2012 etoricoxib is a selective cyclooxygenase cox2 inhibitor, approved in europe for the symptomatic treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and acute gouty arthritis. H410 very toxic to aquatic life with long lasting effects. Material safety data sheet material name wood and wood products. Empirical formula hill notation c 18 h 15 cln 2 o 2 s.
Chemical product and company identification product name. Msds shows how the material reacts to environment and how to store it properly. Etoricoxib is a novel cox2 inhibitor with high selectivity for cox2 106 cox2cox1 ratio, as compared to 35 for rofecoxib or 1. Metabolism etoricoxib is extensively metabolised with etoricoxib product code sc218446 recommended use of the chemical and restrictions on use for research use only. Precautionary statements p210 keep away from heat, hot surfaces, sparks, open flames and other ignition sources. This product is a clear colorless to yellow liquid and is odorless. During all fire fighting activities, wear appropriate protective equipment, including self contained breathing apparatus. View detailed export data, price, monthly trends, major exporting countries, major ports of etoricoxib.
Chemical storage and segregation cornell university. Etoricoxib is a nonsteroidal antiinflammatory drug nsaid that exhibits antiinflammatory, analgesic, antioxidative, anticancer, antiangiogenic, and chemopreventive activities. Formation of toxic gases is possible during heating or fire. Extinguish with alcoholresistant foam, carbon dioxide, dry powder or water fog.
Treatment of acute pain etoricoxib should be used only for the acute painful period. Gb5001 page 1 of 7 fast setting joint compounds date. Ghs safety data sheets sdss a material safety data sheet msds safety data sheet sds is designed to provide both workers and emergency personnel with the proper procedures for handling or working with a particular substance. However, etoricoxib has little activity against cox1 with a ki of 167. Dod hazardous material information ansi format for. Arcoxia 30 mg filmcoated tablets arcoxia 60 mg filmcoated tablets arcoxia 90 mg filmcoated tablets arcoxia 120 mg filmcoated tablets 2. Safety data sheets sds are developed by chemical manufacturers to provide. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Sds of etoricoxib, safety data sheets, cas 202409334. Material safety data sheet according to eec directives 91155eec and 93112ec dplubricant blue 20000201 product name. Material safety data sheet of etoricoxibd4 abmole bioscience.
As in any fire, wear a selfcontained breathing apparatus in pressuredemand, mshaniosh approved or equivalent, and full protective gear. Dod hazardous material information ansi format for cornell university convenience only pinesol cleaner the information in this document is compiled from information maintained by the united states department of defense dod. Naphthalene material safety data sheet cas no 9120. The vertere inventory manager is a multimodule inventory management system for control of materials used in. Ankylosing spondylitis the recommended dose is 60 mg etoricoxib once a day. Discriminatory dissolution method development and validation. P202 do not handle until all safety precautions have been read and understood p264 wash hands thoroughly after handling p270 do not eat, drink or smoke when using this product. Etoricoxib united states pharmacopeia usp reference standard synonym. Brian birmingham, asokumar buvanendran, in practical management of pain fifth edition, 2014. Metabolism etoricoxib is extensively metabolised with etoricoxib. It is a widely prescribed antiinflammatory drug available in tablet strengths of 30, 60, 90, and 120 mg. Comparison of dsc result of the etoricoxib sample w ith etoricoxib crystal form i 1 2. However, there was a higher incidence of ulcers in patients taking etoricoxib relative to placebo. Etoricoxib mk663 is a dipyridinyl derivative that contains a phenyl group attached to the central ring.
Etoricoxib d3 c18h15cln2o2s cid 11772850 structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities. Welcome to the winter safety page, where you can find all your winter safety needs. Cornell university ehs office internet msds sites science lab list of msds. Material safety data sheet page 2 of 7 emergency overview. Etoricoxib provided similar symptomatic relief to nonselective nsaids in patients with these conditions, and to celecoxib in patients with osteoarthritis. Etoricoxib is a nonsteroidal antiinflammatory drug which mainly inhibits the cyclooxygenase2 enzyme see cox2 inhibitors, aust prescr 2000. Formulation of etoricoxib into immediate release tablets. Etoricoxib may be associated with more frequent and severe hypertension than some other nsaids and selective cox2 inhibitors, particularly at high doses.
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